I was having hot flashes (but rather "warm" flashes for me) all day and night. Do not take this medicine in larger amounts or for longer than recommended. won't take me off them either. I hope this helps someone. I have been on Prempro (lowest dose available) for 10 years and love it!! Compare all 145 medications used in the treatment of Postmenopausal Symptoms. I have only been on this medication 48 hours and I am a different person already Tell your doctor if you are breast-feeding. My night sweats, heart flashes, tiredness, weight gain, energy and depression was unbearable. 62% of reviewers reported a positive experience, while 22% reported a negative experience. Take once-a-day antihistamines in the evening. I'm 72 and STILL suffering from hot flashes. A: Prempro is a medicine that contains two kinds of hormones: estrogens and a progestin. So started low dose Prempro. Other than this I have had no other bad side effects; have been on this medicine now for approximately 6 months. My sex drive is non-existent but I have a new, very strong, cuddle drive. At 12 weeks, there was no significant difference in mean TSH levels between the morning and evening dosing groups (5.13 mIU per L vs. 3.27 mIU per L; P = .31). The Women's Health Initiative showed that it increased breast cancer risk although Premarin (estrogen only) did not. But before returning me to HRT she had me try venlafaxine. Take 2 PrEP pills between 2-24 hours before sex. I highly recommend this product, but the cost is way too high. Using this medicine can increase your risk of blood clots, stroke, or heart attack. Been taking Prempro 0.3/1.5 mg for almost 2 months and the night sweats are gone and sex is much better. Take this medicine only as directed by your doctor. ", "I have been on this medication for 37 days. I believe they could make a synthetic with the same properties of horse urine but apparently they don't care or don't want to spend the money.Read More Read Less. Once-daily antihistamines reach their peak 12 hours . I tried using the App GoodRX and the coupon was for $206.00. These side-effects became unbearable so I had my doctor switch me to. I am going to start half the dose to see how my body reacts. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. I would wake up at night and couldn't go back to sleep - no matter how hard I tried. Call your doctor for medical advice about side effects. We comply with the HONcode standard for trustworthy health information. Does it work? Many people consider calcium to be a vitamin, but its actually a mineral. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. I'm 57 now and I plan on taking this low dose for the rest of my life. Read More Read Less. I was having 4 per hour, each lasting 4-6 minutes, 24/7. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. In a 24-week period, patients missed a mean of 1.3 capsules in the morning and 1.9 capsules in the evening (P = .54). Prempro contains a combination of conjugated estrogens and medroxyprogesterone. Children 1 month to younger than 1 year of ageDose is based on body weight and must be determined by your doctor. . I started out at a full dose and quickly realized it was way too much. Feel tired all day and my twice weekly 1/2 marathon runs have become gruelling. Multivitamins can be trickier: They often contain both water- and fat-soluble vitamins. And sex.forget it! The dose is usually 5 to 20 mg once a day before a meal. Clinical Inquiries provides answers to questions submitted by practicing family physicians to the Family Physicians Inquiries Network (FPIN). I have noticed caffeine and stress brings on the flashes. Estrogen is necessary for many processes in the body. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals. After taking Premarin for 49 1/2 years at age 79 1/2 years old my doctor wanted me to quit premarin gradually. information submitted for this request. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Read all patient information, medication guides, and instruction sheets provided to you. Prempro may increase your risk of developing a condition that may lead to uterine cancer. All rights reserved. But side effects may affect when you choose to take paroxetine. My thing was the night sweats, vaginal dryness, painful intercourse and no interest in sex at all which my husband was not thrilled about. Im 61 y.o. No side effects that I'm aware of. Helpful. This medicine should come with a patient information leaflet. Dr. Perez-Gallardo says its less about time of day and more about syncing the habit with your eating and drinking schedule. Do not crush, break, or chew the capsule or the tablet. More detail and references are included on page 277 280 of Discover Your Menopause Type. Downside it is expensive. I was really moody, starving all the time, tired and unmotivated and gaining weight. Tonight will be my 4th dose and I honestly cannot wait to see how I feel after a week. So..I started cutting the tablet (thank heavens it was hard) into two pieces with a pill splitter. Bedtime administration significantly decreased TSH levels by 1.25 mIU per L compared with morning administration (95% confidence interval, 0.60 to 1.89). To help relieve this pain, antacids may be taken with omeprazole, unless your doctor tells you otherwise. The first study on this drug was totally flawed I haven't figured out what starts the night sweats, so i keep my house 70 degrees and below sometimes to sleep. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. I was back to the hormone level of an 11 year old. Hello Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. I've noticed I am less tolerable (that could be my age) of things I normally would be. To use the delayed-release oral suspension: If you are using the delayed-release oral suspension with a nasogastric or gastric tube: The dose of this medicine will be different for different patients. 2005 - 2023 WebMD LLC. As I side note I was on birth control pills for 20 years", "I have only been on this medication for four days, praying it begins to do its job and that I dont get any side effects.. You should not use Prempro if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will be having major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina. I stopped taking the Prempro without doing a taper. So The million dollar question is will the symptoms start where they left off and run for five years? The hot flashes are back just as bad as 8 years ago. Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox, How to Live Life Better With Your Migraine. Without insurance, it would cost well over $200.00. Your doctor may adjust your dose as needed. Children 1 to 16 years of ageDose is based on body weight and must be determined by your doctor. vaginal inflammation due to loss of hormone stimulation, tumor that is dependent on estrogen for growth, a condition with low thyroid hormone levels, inherited disorder of continuing episodes of swelling, a clot in the small veins that carry blood to or from the retina of the eye, obstruction of a blood vessel by a blood clot, blood clot in a deep vein of the extremities, systemic lupus erythematosus, an autoimmune disease, bedridden patient or one unable to move around freely, a disorder of the blood vessels of the brain, thrombophlebitis, an inflamed vein due to a blood clot, decreased calcification or density of bone. And yes, some women are given progesterone at night to help them sleep. YOu could do the bioidentical hormones.But being on prempro that long, I don;t think any herbs are going to help at this point. Took about three weeks for me to notice any benefits: hot flashes were nearly gone, brain fog was lifting, mood was improving. For patients receiving continuous feeding through a tube, feeding should be temporarily . ", "I was prescribed Prempro 6 years ago at age 53.5 and it proved to be very beneficial. optic disk edema . Premarin (conjugated estrogens) can be taken in the morning or at night as long as it is taken at the same time every day. I would rather deal with the hot flashes and hair loss than the acid reflux flare ups. My insurance charges over $670 a month due to deductible. I am on day for of the Prempro and this stuff is awesome. If we combine this information with your protected Tell your doctor right away if you become pregnant during treatment. I have noticed a huge difference in dryness in a vagina which is awesome. That was perfect. I was put on prempro cause of hot flashes and night sweats and vaginal dryness. So, youll want to be careful and not overdo it with calcium. Does taking levothyroxine in the evening vs. morning reduce its effectiveness for reducing thyroid-stimulating hormone (TSH) levels? My husband expressed concern at how my mood had collapsed, and I had to keep retreating to bed to nurse my headache. My symptoms I was having were hair loss, hot flashes and I was mean and hateful. My OBGYN says I can continue to take it as long as I'm finding it beneficial. It's been several years since I quit taking Prempro due to constant yeast infections of which the Dr. didn't believe me. Has not increased my desire for sex either. I have never heard of that. so when you stop the thearpy you body will start its hormone deficiency symptoms again. The benefits of Prempro do not out weight losing a life from heart failure. Prempro gave me my life back. Does it work? I had severe depression, and anxiety, I couldn't focus, and I couldn't function. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. For oral dosage form (powder for suspension): To prevent upper gastrointestinal tract bleeding in seriously ill patients: AdultsThe first day: 40 milligrams (mg) for the first dose, then after 6 to 8 hours, a second 40 mg dose. If some of these hormones are too high in the evening, they interfere with the release of night-time hormones. And you dont need much: Dr. Perez-Gallardo says even small amounts of low- or whole-fat milk or yogurt will do the trick. Anyone experiencing the same symptoms, they should try this medication and take your life back! Take this medicine with food. If it causes sleepiness I should take it at night.But I have read both opinions. Patients received each regimen for 60 days, and TSH levels were measured at the end of each phase. The long-term risk of taking Prempro may be an increased risk for breast cancer, heart disease, stroke and blood clots in the legs or lungs. Sometimes I experience leg/hamstring cramps and a lack of interest in things I used to enjoy. I was prescribed 200mg of progesterone nightly as part of my HRT for transitioning from male to female. Do not keep outdated medicine or medicine no longer needed. Hopefully that will continue. Create an account with us and you'll be able to: Fill in your email below to request a new password. For oral dosage forms (capsules, delayed-release capsules or suspension, or tablets): Adults20 milligrams (mg) once a day before a meal. I quit taking it and the yeast infections never came back but left me. I did. Your doctor may adjust your dose as needed. Skip the missed dose if it is almost time for your next scheduled dose. Good to hear from you again, Lisa. I watch everything I eat and workout at least 5 days a week, so this is disheartening. Theres was a 330 million dollar lawsuit against prempro. As soon as I started this medication, I started feeling less tired and my mood was much better. I noticed a difference in 2 days! Mood swings are still there as well so Im hoping after 1 week I see a big change.. wish me luck", "I started Prempro in 2009, still taking it 9 years later at age 62. This content does not have an English version. It didn't help either, and the "detoxing" was horrible. Premphase: There are 2 different colored tablets in the package. I noticed that when I put a washcloth next to my bed (in a plastic bag not to ruin furniture) at night to place on my chest when the flashing starts, helps it to subside immediately. I can't afford it at that price. I take 1/2 .3 pill every other day. It saved my life. Medication compliance was not reported. Maddie, so glad to hear that you're getting some relief! Do not chew or crush the pellets. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Tell your doctor about all your current medicines and any medicine you start or stop using. ", "I feel normal again. Lost all sweating symptoms and skin became less dry, although skin is itchy. Drug class: Sex hormone combinations. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Take omeprazole capsules or delayed-release capsules before a meal, preferably in the morning. This is not a pleasant drug to go off as all the synptons u went on it for come back.i have been using it for over 20 years. Viewer Questions from Good Morning America . Keep from freezing. My psychiatrist suggested this and I was able to function again in all aspects of life. Within two weeks, I felt so much bette. I already had acid reflux and Prempro made it even WORSE! Thanks for the article. My Doctor told me it could take up to 4 weeks to see results. My doctor put me on a low dose which helped a little, then increased to 0.625mg. I was actually able to sleep my full time without waking up!!! The dose is usually 2.5 to 10 mg once a day before a meal. After one month, my hot flashes were the worst they had ever been and I had a continuous headache. The only objection I have is the urine from horses. Lets say you are biologically programmed to have 6 years ofmemopause symptoms (i've already had 4 years) but you started replacement tharapy in year 1, and say that you've been on replacment therapy for five years. They go by your income. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. - this has improved some, but not happy with the mood swings and spotting. While they are important throughout pregnancy, the best time to start taking prenatal vitamins is before you're pregnant when you're planning to conceive, says Dr. Perez-Gallardo. We do not endorse non-Cleveland Clinic products or services. I will be looking at other options where I might be able to get it through the mail from a different pharmacy. I was hoping after 8 years, I might not need Prempro any longer so weaned myself off. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). I do experience increased appetite, occasional constipation; gained 10 lbs. Your doctor may prescribe a progestin to take while you are using this medicine, to help lower this risk. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. I found this very helpful", "I am a 56 year old women in post-menopause. I started having headaches - which was very unusual for me. Changes clothes or I'd start freezing, even in mid summer. I was told that I was too old for hot flashes. I feel great on this drug and have had no side effects. I need some help on what to do but I don't know who to talk to. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Weakness, tiredness, shortness of breathe are common signs of Prempro and can also be an indication it maybe damaging your heart. And yes, some women are given progesterone at night to help them sleep. If you decide to stop because you're at low risk of infection, one of the great things about PrEP is that you can always start again, as long as you get tested for HIV beforehand. has an average rating of 7.2 out of 10 from a total of 45 reviews Take Prempro exactly as prescribed by your doctor. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. I started this medication about a week ago, and have not had any issues with it yet, but I have not had any relief with my hot flashes yet and was just curious what others thought. Have not had a period in 5 years and after starting on this, had discharge and slight spotting, always needing a pantie liner. Had a partial colon resection, especially if doctors removed part of your ileum (where vitamin B12 is absorbed in your intestine). Follow all directions on your prescription label. hydrochlorothiazide, alendronate, estradiol, Fosamax, Prolia, calcium carbonate, Premarin, Estrace, Tymlos, Yuvafem. But ended up gaining 50lbs and also, developed breast cancer at the age of 62. I'm looking at different options. Store at room temperature away from moisture, heat, and light. Available for Android and iOS devices. As 4 the severe side effects go through most drugs u take and u will see the same ones. I think taking it the same time everyday has helped with that. And I really do not want that weight gain. I had one pregnancy. Answers are drawn from an approved set of evidence-based resources and undergo peer review. Prempro: Take 1 tablet by mouth once daily. I quit it after telling my doctor and will suffer my menopause symptoms! . Hormone therapy has long been the standard treatment for relieving menopausal symptoms: hot flashes, night sweats, and vaginal dryness. The effectiveness of levothyroxine for reducing TSH levels is most dependent on the timing of meals in relation to drug administration. ", "I was prescribed .625 Prempro at the age of 38. My husband retired a couple months ago so I lost insurance. I started Prempro and I haven't had a seizure, panic attack, confusion or anything else since.. even after stopping all of my anti-seizure medications. I used to have to strip down and sit in front of a fan just to enjoy a cup of coffee. I sure hope to find something", "I'm 44 yrs old. Your body makes testosterone, progesterone, estrogens, DHEA, cortisol, thyroid hormones, etc., on a 24 hour basis. Add 5 mL to a catheter tipped syringe and then add the contents of a 2.5 mg packet (or 15 mL of water for the 10 mg packet). I plan to stop medication. so when I read your blog. Changes to meal timing, medication compliance, or levothyroxine timing occurred at a rate of 1.2%. As 4 the severe side effects go through most drugs u take and u will see the same ones. vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding. The Best IOL for 2022 RXSight Light Adjusted Lens, Will refractive surgery such as LASIK keep me out of glasses all my life. I am going to give it 3 months as this is the supply that I bought. Policy. Do not open the capsule. Allow your doctor to determine the time frame that you should remain on Prempro. It's unclear whether these risks apply to a younger woman who's on Prempro due to premature ovarian failure or POF. - "And I looked prempro up and it has a cancer fighting drug in it too." Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Saving the best for last, it restores the vagina from the ravaging effects of menopausal changes such as dryness and pain during sex. Prempro should be taken according to your healthcare provider's instructions, which they may decide is best in the morning or at night. To treat erosive esophagitis caused by acid-mediated GERD: Adults and children 17 years of age and older20 milligrams (mg) once a day before a meal. Take water-soluble vitamins on an empty stomach with a glass of water, recommends Dr. Perez-Gallardo. Apparently it does. She was reluctant but I had already tried black cohosh, green tea and 3 different OTC drugs that were supposed to relieve the hot flashes. Using Prempro can increase your risk of blood clots, stroke, or heart attack, or cancer of the breast, uterus, or ovaries. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Used with permission. Find everything you need to know about Premarin (Conjugated Estrogens (Oral)), including what it is used for, warnings, reviews, side effects, and interactions. If interested in submitting questions or writing answers for this series, go to https://www.fpin.org or email: questions@fpin.org. It's been several years since I quit taking Prempro due to constant yeast infections of which the Dr. didn't believe me. My gyno started weining me off last winter. Like. But she had my medical records showing I was on the Boniva, Vit. And I do feel a little bloated. Folic acid is essential for the development of your babys neural tube. Not only has it decreased my hot flashes and mood swings (I have reduced desire to strangle people, LOL), but also lessened the frequency of my migraines and helped to calm my IBS-D issues -- two things I wasn't expecting. The dose is usually taken together with clarithromycin or clarithromycin plus amoxicillin. I started Prempro two weeks ago and I am officially hot flash free and happier then I have been in years! I will sit down maybe an hour after taking the Prempro and it feels like I'm super relaxed or sleepy. a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina. I shared this with my doctor and she suggested I get back on Prempro. I am 52 and haven't had a period in almost a year. My Dr gave me a prescription for Prempro. After reading these reviews, this med scares me a little. My doctor said she believes it would kick my weight in gear and I should start losing, a little worried now after reading some comments however I have noticed a big change in my want to eat.. this is really good!!! ALSO FLUID RETENTION IS NOT WORTH THE 10 POUNDS IN TWO WEEKS. Children 1 year of age and olderDose is based on body weight and must be determined by your doctor. I asked to please stay on Prempro as I believe my quality of life is far more important than the slight risks associated with extended use. WebMD does not provide medical advice, diagnosis or treatment. I contacted Pzier I received this medication for free. She reluctantly prescribed another year. Last updated on Feb 20, 2023. So..I started cutting the tablet (thank heavens it was hard) into two pieces with a pill splitter. Prempro is a daily medication that should result in relatively stable levels regardless of timing. 3 If you have or have had cancer, talk with your healthcare provider about whether you should use PREMPRO or PREMPHASE. I just recently had a spot on my mammogram that scared me which turned out to be a cyst. Has worked extremely well and also supports my waning, menopausal sex drive. All rights reserved. Prempro has an average rating of 7.2 out of 10 from a total of 45 reviews for the treatment of Postmenopausal Symptoms. Prempro may increase your risk of developing a condition that may lead to uterine cancer. There are other ways to restore healthy sleep. But before returning me to HRT she had me try venlafaxine. Now my pcp wants to put me on anxiety med and I'm not OK with that. Taking vitamins can be a great way to support your nutritional needs but there is a right way to do it. Take Hormones Once a Day in the Morningby Joseph J Collins, RN, ND. My husband and kids say I'm more moody, and not myself. Overactive Bladder: Could You Live Better? You could also end up with an upset stomach. Also want to mention that since menopause, I have zero Interest in sexual relations with my husband. Policy, When people dont take vitamins the proper way, they dont see improvement, says family medicine doctor Rodolfo Perez-Gallardo, MD. And while you're at it, also take 400 micrograms of folic acid daily three months before you plan to get pregnant. The complete database of evidence-based questions and answers is copyrighted by FPIN. Avoid smoking. Available for Android and iOS devices. Your hormone levels are naturally higher in the AM and lower in the evening. Prempro HOT FLASHES ARE BETTER THAN THE AMOUNT OF WEIGHT GAIN AND FOOD CRAVING FROM THIS DRUG. No more! For more on the findings of this study, see the article on the WHI Study. old. I have new insurance, but my co-pay used to be $20.00. Fat-soluble vitamins require fat for your body to absorb them. Ask your doctor if you have any questions. My hair stopped falling out. I took this medication for three days. Read More Read Less, Took about three weeks for me to notice any benefits: hot flashes were nearly gone, brain fog was lifting, mood was improving. Version: 12.03, hydrochlorothiazide, alendronate, estradiol, Fosamax, Prolia, calcium carbonate, Premarin, Estrace, Tymlos, Yuvafem. One reason was some benign cysts diagnosed on my annual mammogram and ultrasound. All Rights Reserved. I watch everything I eat and workout at least 5, days a week, so this is disheartening. My hot flashes have dwindled to just a slight warmth and I can tell my attitudes a lot different I can see the light again my menopause started in 2014 my last menstrual cycle was June 2017 it has been miserable until yesterday thank you, Started it in my 40s stopped at age 84 one year later got osteoporosis had terrible hot flashes and night sweats now back on doctor warned about blood clots, I started taking Prempro when I was 50. If you eat a nutritious, balanced diet, you do not need these supplements. Maddie6. Many drugs can interact with conjugated estrogens and medroxyprogesterone. ", "I have been on Prempro, the lowest dose, for almost three months now. Ten months ago I made the decision to wean off Prempro, and I can honestly say it was the worst decision. So the internet says take it ASAP. I have also noted a decrease in my appetite which for awhile there was the same as a teenaged boy! ", "Menopause started at 50. Now my heat flashes, night sweats and weight gain has stopped! This series is coordinated by John E. Delzell Jr., MD, MSPH, associate medical editor. Within 4 days, hot flashes subsided, within 1 week, they were gone! That was 8 years ago. My recovery is still on going but Im healing daily . : No, it will not. Anxiety is gone, so is the emotional crying over anything, All the mood swings are gone. Prozac (fluoxetine) is generally recommended to be taken in the morning, but can safely be taken at any time during the day. Good luck!". Those meds have many side effects and the risk of suicide is much higher than the risk of breast cancer with Prempro. I have been suffering with hot flashes for 16 years and I finally decided that I cannot do this anymore. No hot flashes anymore! I started having headaches - which was very unusual for me. It's been eight weeks since I've stopped. Ask your healthcare professional how you should dispose of any medicine you do not use.